Sulfasalazine Side effects?

Posted Wed 11 Feb 2026 13.25 by RickOsteo

I was put on hydroxychloroquine last September for my Psoriatic arthritis and it made no difference and I had a huge 3 week flare up in December . I’ve now been put on Sulfasalazine which I’ve taken for two and half weeks . I understand it can take 8 weeks or so for Sulfasalazine to start working but since I started taking it I’ve been more fatigued than ever , totally flattened . Various day to day aches are as previous but it’s mostly the fatigue that’s getting to me . Has anyone else had that effect when taking Sulfasalazine or is this my untreated arthritis fatigue?

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