It’s great to see so many people with positive experiences with Methotrexate. I don’t in any way wish to put a downer on things, just feel you may want to hear from a bad experience. I have psoriasis and psoriatic arthritis, and after a failed steroid injection directly into one of my knees, and naproxen not touching the inflammation, I was prescribed Methotrexate. My arthritic symptoms improved slightly, I no longer had problems with my hips, and my knees and feet were noticeably improved but still only around 30% useable. My psoriasis didn’t worsen or improve at all.
I was fortunate not to get any of the physical side effects, hair loss being my main worry, however, I had a drastic change in mental well-being. I was an emotional wreck, breaking down into fits of tears just because someone said “hi, how are you?” and some days the crying wouldn’t stop for 6 or 7 hours.
Thinking I was just not coping with my arthritis and the drastic change to my lifestyle due to the arthritis I was sent to a psychiatrist. He concluded that I’m stressed, I have signs of depression and understandably so, I’m 27 and my whole world has been turned upside down.
Due to my GP surgery closing and communication issues with my new one, I ended up being unable to get my prescription and after 2 weeks of not being on the Methotrexate, I was 100% mentally better. No more crying episodes, and back to my bright bubbly self (just still no skipping and jumping as my legs simply won’t allow it)
Having seen my Rheum Doc a few weeks ago, he and my psychiatrist have decided the best thing for me is to not go back onto the Methotrexate and I’m looking forward to starting some Biological treatment in the coming weeks.
Personally, I’m willing to give anything a try to attempt to live a normal active life again, and I would encourage anyone offered treatment from their doctor to give it a try. If it doesn’t work, at least you know and can try something else.
But just make yourself fully aware of the potential side effects, and prepare those around you for that, as it may be someone else who notices changes in behaviour etc whereas you’re more likely to notice any physical changes.
I hope everything works out for you, sorry for the essay haha