Constantly changing symptoms of PSA

Posted Tue 25 Dec 2018 6.42pm by Paul macbay
Hi. I'm Paul and I have had guttate & plaque psoriasis from the age of 4 and recently PSA which first started in my teens but was missed.

Hi and merry Christmas.

I've had psoriasis and now it appears PSA, for many years but the PSA went undiagnosed until last year when symptoms increased dramatically after an operation I had. So far a combined treatment of methotrexate and Leflunomide has not stopped flare ups or improved bad morning stiffness and sharp pains in various joints but mainly the tendon attachments. I am hoping to be moved onto the biologic treatments in the new year. Until recently it was down one side of my body (right hand, ankle and foot right hip and shoulder) it's now starting to show in my left hand fingers

Has anyone experienced this and could it mean it's getting worse?

Also has anyone experienced an improvement with the switch from Dmards to biologic treatments?

Thanks for reading. Paul

Posted Sun 30 Dec 2018 11.25am by wendyloish

Hi Paul,

I had left this one in the hope someone else with experience with various Dmards would answer it. And I already answer, perhaps some people might suggest, too many queries outside my experience. But people are sometimes disappointed when their questions go without a response.

From the above you may gather that I have not any first hand experience of the medications you mention. But I do have psoriatic arthritis, and it does affect one side of my body more than the other. For me it is the left side, with my left foot often swelling up with sausage toes. The morning stiffness is mostly about my back and my left hip. But that, and the associated pain, are gone now, controlled by elimination of inflammation causing foods from my diet.

As far as getting worse is concerned, that would be expected, unless the inflammation was somehow brought under control. In the last 4 years CT scans of my lower back have shown a marked deterioration to the point of nerve root impingement. I am hoping now that getting the inflammation under control will slow down the progression of the deterioration, if not halt it altogether. Only time will tell, although if the decrease in pain and stiffness is anything to go by, I am succeeding.

Have a look at diet, and try eliminating the worst offenders, gluten, lactose, and fuctose. At the least you may get better results than with your medication alone.

Good luck and Happy New Year!


Posted Mon 14 Jan 2019 7.28pm by Dmort

Hi Paul

I have just stopped with apremilast, was on for 6 months, and before that methotrexate,unfortunately they didn’t work for me, so It’s definitely different outcomes for different people. Good luck.

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