Anyone on Skyrizi?

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Posted Fri 31 May 2024 18.21 by polar

Agreed. Everyone react differently. :) I had similar feeling when I first started the injection but no apparent improvement at the beginning. It takes time for your body to react to the injection. I still continued to use the Enstilar after the 1st injection until I saw the improvement. It took me a few months to get to a state that only have the red marks left. As you like us has been throught so much to get on Skyrizi, give it some time and try not to stress yourself. Cheers :-)

Posted Fri 31 May 2024 18.42 by Luke0911

Thank you both - sorry to be a pain and ask one more question - when you first started the injection, how long before the psoriasis slowed down? What I mean by that is that I’m still having new patches appearing. Did you guys still have new patches appear for at least a little while after starting the injection before it stopped?

Posted Fri 31 May 2024 18.54 by polar

No worries. I understand the pain in waiting for the improvement to come. It took me roughly a month to start stopping from getting worse. After that time, patches are gradually disappear but it still took roughly another month to become obvious. In total, I can see an improvement to PASI90 after two months since the first injection. For nails, it takes much longer to get improved, it took me nearly a year or so before my nails are back to normal. I now still have one small patches on my left and right leg and some small patches in my forehead. Apart from that, other parts of my body are clear. I can live with these small patches compared to where I was. Everyone react differently, some may react slower than others but with better result and some are vice versa. Feel free to ask any questions if you still have any queries. :-)

Posted Fri 31 May 2024 19.05 by truban26

I still got new patches for the first few weeks then started to notice improvement. I know this is scary and frustrating.

Posted Fri 31 May 2024 19.07 by truban26

I am pretty much 100% clear now!

Posted Mon 3 Jun 2024 19.51 by Luke0911

Sorry to ask another question - if you have continued using topicals during the first bit of the injection such as Enstilar - how did you know if the injection was working or if it was just the Enstilar?

Posted Mon 3 Jun 2024 20.08 by polar

To me, the outcome is very different. With Enstilar, my skin were still with very red patches. Once the Skyrizi kicks in, the pain and the itchiness from the psoraisis were largely reduced ans gradually gone.

Posted Mon 3 Jun 2024 20.11 by truban26

I used my topicals for a week or so but they weren't really helping anyway (which is why i went on Skyrizi) so the difference was definitely the Skyrizi.

Posted Thu 27 Jun 2024 16.00 by Luke0911

Hi Polar and Truban26: I am now 5 1/2 weeks into Skyrizi (1 1/2 weeks past my loading dose). I have started to see some minor improvements, with my scalp much better, however it is still very slow. My patches seem to be clearing slightly from the middle of them outwards (not sure if this is normal). When the medicaiton kicked in for you both, was it still a slow clearing/healing process? I saw my dermotologist today who has actually suggested using Enstilar at this point every day for the next 4 weeks to speed things up. My concern is the re-bound effect of stopping Enstilar (I know a lot of peoples psoriasis comes back worse). In your opinions, shall I just leave the injection to carry on doing its thing, or use the Ensitlar? Do you think that since the injection has potentially kicked in now, there should technically be no re-bound after stopping Enstilar? Sorry for the long one, appreciate you both!

Posted Thu 27 Jun 2024 17.08 by truban26

I has results in a month after starting the injections. I will never offer medical advice as I am not a licensed medical provider however, if I were you, I would probably just give the Skyrizi some more time. It seems to be working and I get that instant gratification is something society has grown accustomed to in the digital world but sometimes thing just take longer than we want them to and we just have to be patient. It really hasn't been that long yet. Be patient! I'm sure it will all be ok!

Posted Thu 27 Jun 2024 18.01 by Luke0911

Hi Truban26, thank you so much for that, I agree! How long from the moment you noticed the first sign of movement did it take before you were clear ish? I think the injection has now taken hold but I’m wondering how long the healing of your skin/fading process takes etc.

Posted Thu 27 Jun 2024 18.19 by truban26

Like I said before, it took about a month for me to see results and by month 2, I was 99% clear. As far as fading process, everyone is different. I am pretty much clear of everything at this point.

Posted Wed 24 Jul 2024 16.09 by truban26

I have a question for the group. Has anyone gone off Skyrizi during pregnancy and had success getting back on it? My boyfriend and I want kids but I am worried about messing with my medication and the consequences of going off of this drug. Thanks in advance!

Posted Wed 31 Jul 2024 05.15 by Elaine27

I’ve had 2 pregnancies.. both times psoriasis significantly improved during pregnancy then came back with a vengeance after hence having to restart back on biologics.. but psoriasis seems to be quite minimal during pregnancy as I’ve heard the same from others!

Posted Wed 31 Jul 2024 15.24 by truban26

I am more concerned about the risk of going off Skyrizi and trying to get back on it. Did you have a hard time going back on biologics? Did your body become immune to it?

Posted Wed 31 Jul 2024 22.46 by Elaine27

For me the effect was the same after restarting no issues
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