Immune system question

Hello, I have psoriasis and psoriatic arthritis for plus 10 years, in terms of psoriasis is very mild with let's say 10% in terms of psoriatic arthritis I have on both feet, both ankles, both knees and spine . I'm on cosentix for 8 months and saw a lot of improvement. My history/battle I started with methotrexate 3 rounds to find I can't take because my liver will crush down, then I started Adalimumab and was working wonders for 6 months then my immune system started to kill/destroy the medication ( even took samples for a study) and finally I'm on cosentix. It's me or someone has the same problem even with treatment making weaker against flu my body just cure the flu in 3 days, I wish I was joking 3 DAYS and then I'm beat with the arthritis the whole month until I get the next injection. This make sense to anyone? Is my immune system adapting?