Hi all,
My dermatologist has recommended I go onto methotrexate tablets for my psoriasis.
I want to hear people’s stories good and bad. I am reading reviews which are both positive and negative.
Thanks
Posted Thu 16 Oct 2025 09.36 by Rachel
Hi Billy
I started Methotrexate yesterday, and like you - would really value hearing other people's experiences.
Hope it works for you!
Posted Thu 30 Oct 2025 23.43 by P sufferer for over 20 years
I am also keen to hear people's experience of Methotrexate as I've had the 'work up' done for it (arranged by the community dermatologist) and waiting for my appointment with the hospital dermatologist in January before I start.
Is this the first line of tablets they prescribe?
Rachel, what is your experience so far?
Posted Fri 31 Oct 2025 11.43 by LJ
I've been prescribed it too but nervous about side effects especially as I have Alpha-1 anti-tripsine deficiency.
I've had the pre blood work done and a chest xray. Think ive had this condition years but it's only just been diagnosed.
I'd love to hear everyone's experience of it.
Posted Tue 4 Nov 2025 16.40 by Disco Dave
I have been using methotrexate now for 3 years. I suffered from psoriasis around my ears, on my legs, knees and elbows and under my toe and fingernails. As I suffer from arthritis my consultant was concerned that I had developed psoriatic arthritis as well as rheumatoid arthritis. She prescribed methotrexate as she believed it would alleviate my arthritis symptoms as well as possibly helping my psoriasis outbreaks. I started on tablets and after a year was persuaded to switch to injections, self administered weekly, the results were cathartic. I occasionally suffer a psoriatic outbreak on the back of one leg, which I use enstillar to treat if needed. My nails are now clear as are all the other patches that I suffered from. Not bad considering that treating the psoriasis was a bonus to alleviating the arthritis symptoms. I haven’t suffered any adverse effects from the use of methotrexate but am susceptible to coughs and colds. I manage this by being extremely cautious around crowds, especially during flu season.
Posted Thu 13 Nov 2025 23.10 by Steview A P sufferer for over 30 years, through good and bad times.
Methotrexate worked really well for me for ten years. I was never 100% clear but could live a relative normal life.
For one day a week I was groggy with nausea and drowsyness but I accepted that for the benefits. The folic acid should help with the side effects. Good luck
Posted Tue 18 Nov 2025 11.31 by Mag
I was originally prescribed this in tablet form however it did not agree with me and I was then moved on to administering it by injection. After almost a year of trial and error, different doses via both methods, I no longer take this medication as there was no reduction in my symptoms. I have now been given another medication which I self inject on a 2 weekly basis. It is still early days , only about 6/7 weeks in , so will just need to stick with it for a good while yet. For those taking methotrexate and it is helping I would say stick with it as you will always be monitored however not one treatment is suitable for everyone unfortunately. Hope you all do well and get some relief.
Posted Fri 21 Nov 2025 13.14 by Moya
I’ve been on Methotrexate twice for approx a year. Worked really well especially for severe scalp psoriasis. Stopped as hoped to manage without but symptoms returned, second stop due to raised liver test results but false alarm. Now thinking of going back on it, desperate to sort severe scalp & body patches. Everyone is different so worth trying.
Posted Fri 27 Mar 2026 15.10 by Shazza 1968
I started Mexotrexate four weeks ago and can see a slight improvement. I manage the side effects by taking folic acid on the days I’m not taking Mexotrexate. I’ve stopped drinking alcohol too and feel so much better in myself. Here’s hoping to see some significant improvement of my plaque psoriasis in the next few weeks. I’m keeping the faith and have regular two weekly blood tests to check my liver and kidney functions,
Posted Tue 28 Apr 2026 19.43 by Cherry Blossom
Hi, I had methotrexate for 2 years and it cleared my skin and arthritis really well, but it ruined my teeth. Dermatology said they'd not heard of that side effect, but my dentist said they see it all the time, teeth decaying inside with no visible signs on the outside, make sure you get regular dental checks with xrays. I'm now going through extensive dental treatments and switched to adalimumab.
Posted Today 08.54 by Steve
I was diagnosed with RA together with Psoriasis around 2.5 years ago. I was prescribed Methotrexate but I felt very uncomfortable taking this once a week. I will admit this drug did help the symptoms.
Chatting with a friend she suggested taking vitamin D3 with K2 MK7.
I started taking this daily at a dose of 20,000 iu every morning. (Without medical advice) This was my choice.
After six months I felt so much better and started to reduce the Methotrexate over several months and then stopped using it altogether. My rheumatologist disagreed with this action. 1.5 years later my RA has gone. I have reduced the dose of D3 to 10,000 iu daily. I also started using Head and Shoulders shampoo on my head and face, 3 weeks ago. My psoriasis has also 95% gone.
I am not qualified to give you advice but wanted to share with you my little story, I have not been to see anyone at the hospital now for over 1.5 years. Maybe I was misdiagnosed who knows but for me as a engineer being able to use my hands again is wonderful.
Posted Mon 20 Jan 2025 14.22 by Billy2018