Pyzchiva vs Stelara
Posted Fri 29 Aug 2025 13.51 by Ian C
In April I was swapped from Stelara to Pyzchiva and since then I've been far more fatigued than I was on Stelara, my muscles ache a lot, I can do little exercise, feeling a terrible malaise, and have had a sore throat that literally hasn't stopped for one day. I've also had some psoriasis appear on my scalp which makes me think that Pyzchiva might not be as good as Stelara.
I do have CFS (chronic fatigue syndrome) caused by COVID but that's never caused me to feel like this even at it's worse, and the sore throat for these four months is quite a telling sign. I've had blood tests which came back showing that on paper I'm healthy and there are no indications in them at all that there's any underlying health issues.
Has anyone else been swapped to Pyzchiva and had any issues with tiredness/fatigue?
Thanks
Posted Mon 29 Dec 2025 14.46 by GC
Hi Ian C
I was swapped from Stelara to Pyzchiva and after the loading dose, the psoriasis had returned to the level it had been 10 years ago before taking Stelara. I did not have the symptoms you described, but the Pyzchiva led to a deterioration in my condition. I was taken off Pyzchiva and prescribed 2 further biologics which have broken down after 2 weeks and am currently on no treatment, awaiting biopsy results. Several
websites state that Pyzchiva is a direct match for Stelara - I would dispute that as it resulted in worse psoriasis than I have experienced in 10 years on Stelara.
I would suggest you go back to your healthcare professionals and request being prescribed an alternative. if you are experiencing symptoms with Pyzchiva.
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