Ozempic / Mounjaro / Wegovy...

Some very interesting and useful replies. Thanks, everyone. All (self-reported) replies, so far, seem positive. Another recent study suggesting semaglutide, such as Ozempic, might reduce or improve psoriasis by roughly 50-75% in 3 months. https://pubmed.ncbi.nlm.nih.gov/39858442/#:~:text=The%20results%20demonstrated%20that%20the,%3D%2019.8)%2C%20while%20after%2012

I have had psoriasis for 30 years and psa for 15 years but was only recently diagnosed, I have also been on ozempic and now mounjaro for diabetes since 2020, my psoriasis did start to go into remission during the first 6 months but it soon comes back once your body gets used to it, I don’t have any sugar in my diet, I cook everything from scratch, including bread, I don’t eat red meat or any fried foods. I’ve been taking methotrexate for last 3 months and at first it seamed to be working, my skin started to clear, the flare ups became less and the swelling started to go, but now my skin has started flaring up again in new and old places, my pain is a lot worse than before and I’m getting unbearable pain in my back hips and pelvis which before I could cope with, my hands and feet are also a lot worse, the swelling is back with a vengeance and all I want to do is sleep…. but I can’t due to the pain. I take 15mg of methotrexate weekly followed by folic acid the next day, I’m on naproxen and cocodomol for the pain which I cannot survive without. I’m at the rheumatologist again on next week and it can’t come fast enough. Will they up the dose of methotrexate or is this the highest dose for psa ?

Yes it's amazing. I'm on Wegovy almost 3 months and have 90% reduction. It works better than any of the other treatments I've used over the years. And I'm very happy not to use steroid-based scalp treatments that make everything worse. I hope it will be developed as a treatment for all who need it. Maybe as a microdose?

Anybody else seeing psoriasis decrease (or increase) with the fat jabs? One recent (provisional) study suggests GLP-1 fat jabs, like Ozempic, may reduce the risk of heart attack or premature death for psoriasis sufferers by as much as 40-80%, which, while being treated with caution, and could yet be debunked, is (for now) a quite remarkable statistic. https://www.upi.com/Health_News/2025/09/18/france-Ozempic-Zepbound-psoriasis-benefits/5361758208640/

Hi I’m new here, just came across this forum by chance. I’ve been taking mounjaro for 5 months but unfortunately no improvement in my psoriasis. I have lost 2.5 stone and have been taken off blood pressure meds, which is all amazing…and sign that inflammation is improving but I really was hoping it would help my scalp psoriasis. Maybe as I increase the dose it might help.