Ozempic / Mounjaro / Wegovy...

Some very interesting and useful replies. Thanks, everyone. All (self-reported) replies, so far, seem positive. Another recent study suggesting semaglutide, such as Ozempic, might reduce or improve psoriasis by roughly 50-75% in 3 months. https://pubmed.ncbi.nlm.nih.gov/39858442/#:~:text=The%20results%20demonstrated%20that%20the,%3D%2019.8)%2C%20while%20after%2012

I have had psoriasis for 30 years and psa for 15 years but was only recently diagnosed, I have also been on ozempic and now mounjaro for diabetes since 2020, my psoriasis did start to go into remission during the first 6 months but it soon comes back once your body gets used to it, I don’t have any sugar in my diet, I cook everything from scratch, including bread, I don’t eat red meat or any fried foods. I’ve been taking methotrexate for last 3 months and at first it seamed to be working, my skin started to clear, the flare ups became less and the swelling started to go, but now my skin has started flaring up again in new and old places, my pain is a lot worse than before and I’m getting unbearable pain in my back hips and pelvis which before I could cope with, my hands and feet are also a lot worse, the swelling is back with a vengeance and all I want to do is sleep…. but I can’t due to the pain. I take 15mg of methotrexate weekly followed by folic acid the next day, I’m on naproxen and cocodomol for the pain which I cannot survive without. I’m at the rheumatologist again on next week and it can’t come fast enough. Will they up the dose of methotrexate or is this the highest dose for psa ?

Yes it's amazing. I'm on Wegovy almost 3 months and have 90% reduction. It works better than any of the other treatments I've used over the years. And I'm very happy not to use steroid-based scalp treatments that make everything worse. I hope it will be developed as a treatment for all who need it. Maybe as a microdose?

Anybody else seeing psoriasis decrease (or increase) with the fat jabs? One recent (provisional) study suggests GLP-1 fat jabs, like Ozempic, may reduce the risk of heart attack or premature death for psoriasis sufferers by as much as 40-80%, which, while being treated with caution, and could yet be debunked, is (for now) a quite remarkable statistic. https://www.upi.com/Health_News/2025/09/18/france-Ozempic-Zepbound-psoriasis-benefits/5361758208640/

Hi I’m new here, just came across this forum by chance. I’ve been taking mounjaro for 5 months but unfortunately no improvement in my psoriasis. I have lost 2.5 stone and have been taken off blood pressure meds, which is all amazing…and sign that inflammation is improving but I really was hoping it would help my scalp psoriasis. Maybe as I increase the dose it might help.

I've been on Mounjaro 2.5mg for around 7 weeks going onto 8 weeks now. I've had the opposite effect unfortunately. I've suffered with psoriasis since i was around 7 and it's always been bad on my face. Sadly my psoriasis started spreading to my legs and arms since taking it, however, i will mention i had tonsilitis around 4-5 months ago and it's usually a trigger for me. I heard there can be a 3 month delay from onset of tonsilitis to getting guttate psoriasis. I thought i'd mention this as it may not be the jab flaring me up but it has got worse since i started. I have lost weight though and feel calmer in myself, i'm just gutted i've got psoriasis spreading. Another thing to mention is i started getting it in areas i've never really had it before. I will post a update in a few months if i remember to see if i do eventually get improvements as i feel like it's still early days.

Thanks, all. Great feedback. So far, for self-reported treatment, it looks like psoriasis experiences on the fat-jabs are roughly 80-90% positive, and 10-20% negative or neutral.

Interesting new study, which suggests that losing around 5-10% of bodyweight, via better diet, could roughly double one's chance of future psoriasis clearance. A significant improvement. The research suggests about 80% of psoriasis patients in the West are overweight or obese, which is an extremely high rate. The "psoriasis-obesity cycle" is real. The study suggests that the first step to clearing psoriasis should always be to get on the bathroom scales and see if one needs to lose (or gain) weight. For example, if one's BMI today is 35, taking it down to 25 tomorrow should help lower redness, flakes, itching, etc. Gain weight, gain psoriasis. Lose weight, lose psoriasis. https://www.patientcareonline.com/view/weight-loss-interventions-improve-psoriasis-severity-and-quality-of-life-meta-analysis-finds