Research Publications

Since awarding our first research grants in 1971, the Psoriasis Association has funded over 200 projects. If you'd like to learn more about the results of these projects, take a look at paper and PhD thesis libraries below.

Paper Library

The availability of the full text for each paper will depend on whether the article is open-access or not. An open-access paper can be read online by anyone and requires no payment, whereas a closed access paper will cost money to read. The abstract or summary, however, should be freely available for all papers. This will give you an overview of the work that has been done and what the researchers found out.

2021

Connexins and the Epithelial Tissue Barrier: A Focus on Connexin 26
L. Garcia-Vega, E. M. O’Shaughnessy, A. Albuloushi and P. E. Martin
Biology, 2021
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2016 - 2020

Melanoma Risk in Patients Treated With Biologic Therapy for Common Inflammatory Diseases. A Systematic Review and Meta-analysis
S. Esse, K. J. Mason, A. C. Green and R. B. Warren
JAMA Dermatology, 2020
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What are the barriers to physical activity in patients with chronic plaque psoriasis?
L. Auker, L. Cordingley, D. R. Pye, C. E. M. Griffiths and H. S. Young
British Journal of Dermatology, 2020
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IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis
M. Catapano, M.Vergnano, M. Romano, S.K. Mahil, S.-E. Choon, A.D. Burden, H.S. Young, I.M. Carr, H.J. Lachmann, G. Lombardi, C.H. Smith, F.D. Ciccarelli, J.N. Barker and F. Capon
Journal of Investigative Dermatology, 2019
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Defining the Therapeutic Range for Adalimumab and Predicting Response in Psoriasis: A Multicenter Prospective Observational Cohort Study
N. Wilkinson, T. Tsakok, N. Dand, K. Bloem , M. Duckworth, D. Baudry , A. Pushpa-Rajah, C.E.M. Griffiths, N.J. Reynolds, J. Barker, R.B. Warren, A.D. Burden, T. Rispens, D. Stocken, C. Smith, BSTOP study group , PSORT consortium
The Journal of Investigative Dermatology, 2019
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Understanding the experience of sleep disturbance in psoriasis: a qualitative exploration using the Common‐Sense Model of Self‐Regulation
A.L. Henry, C. Bundy, S.D. Kyle, C.E.M. Griffiths and A. Chisholm
British Journal of Dermatology, 2019
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Connexin 26 and 43 play a role in regulating proinflammatory events in the epidermis
L. García‐Vega, E. O'Shaughnessy, A. Jan, C. Bartholomew and P. E. Martin 
Journal of Cellular Physiology, 2019
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The prevalence of co-morbidities and their impact on physical activity in people with inflammatory rheumatic diseases compared with the general population: results from the UK Biobank
M.J Cook, E. Bellou, J. Bowes, J.C. Sergeant, T.W. O'Neill, A. Barton, S.M.M. Verstappen
Rheumatology, 2018
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Intentional and Unintentional Medication Non-Adherence in Psoriasis: The Role of Patients' Medication Beliefs and Habit Strength
R.J. Thorneloe, C.E.M. Griffiths, R. Emsley, D.M. Ashcroft, L. Cordingley, BADBIR, PSORT Study Groups
The Journal of Investigative Dermatology, 2018
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HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis
N. Dand, M. Duckworth, D. Baudry, A. Russell, C.J. Curtis, S.H. Lee, I. Evans, K.J. Mason, A. Alsharqi, G. Becher, A.D. Burden, R.G. Goodwin, K. McKenna, R. Murphy, G.K. Perera, R. Rotarescu, S. Wahie, A. Wright, N.J. Reynolds, R.B. Warren, C.E.M. Griffiths, C.H. Smith, M.A. Simpson, J.N. Barker, BADBIR Study Group , BSTOP Study Group , PSORT Consortium
The Journal of Allergy and Clinical Immunology, 2018
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The Connexin Mimetic Peptide Gap27 and Cx43-Knockdown Reveal Differential Roles for Connexin43 in Wound Closure Events in Skin Model Systems
C. Faniku, E. O’Shaughnessy, C. Lorraine, S. R. Johnstone, A. Graham, S. Greenhoug, and P. E. Martin
International Journal of Molecular Sciences, 2018
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Connexin Communication Compartments and Wound Repair in Epithelial Tissue
M. Chanson, M. Watanabe, E. M. O’Shaughnessy, A. Zoso and P. E. Martin
International Journal of Molecular Sciences, 2018
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Human Endothelial Cells Modulate CD4+ T Cell Populations and Enhance Regulatory T Cell Suppressive Capacity
W. C. Lim, M. Olding , E. Healy, T. M. Millar
Frontiers in Immunology, 2018
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Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling
N. Dand, S. Mucha, L.C. Tsoi, S.K. Mahil, P.E. Stuart, A. Arnold, H. Baurecht, A.D. Burden, K. Callis Duffin, V. Chandran, C.J. Curtis, S. Das, D. Ellinghaus, E. Ellinghaus, C. Enerback, T. Esko, D.D. Gladman, C.E.M. Griffiths, J.E. Gudjonsson, P. Hoffman, G. Homuth, U. Hüffmeier, G.G. Krueger, M. Laudes, S. Hyuck Lee, W. Lieb, H.W. Lim, S. Löhr, U. Mrowietz, M. Müller-Nurayid, M. Nöthen, A. Peters, P. Rahman, A. Reis, N.J. Reynolds, E. Rodriguez, C.O. Schmidt, S.L. Spain, K. Strauch, T. Tejasvi, J.J. Voorhees, R.B. Warren, M. Weichenthal, S. Weidinger, M. Zawistowski, R.P. Nair, F. Capon, C.H. Smith, R.C. Trembath, G.R. Abecasis, J.T. Elder, A. Franke, M.A. Simpson, J.N. Barker
Human Molecular Genetics, 2017
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Nonadherence to psoriasis medication as an outcome of limited coping resources and conflicting goals: findings from a qualitative interview study with people with psoriasis
R.J. Thorneloe, C. Bundy, C.E.M. Griffiths, D.M. Ashcroft and L. Cordingley
British Journal of Dermatology, 2017                                         
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Nitric oxide induces human CLA+CD25+Foxp3+ regulatory T cells with skin-homing potential
C. Yu, A. Fitzpatrick,  D. Cong, C. Yao,  J. Yoo  A. Turnbull,, J. Schwarze, M. Norval, S.E.M. Howie, R. B. Weller, A. L. Astier
Journal of Allergy and Clinical Immunology, 2017                   
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An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target
S.K. Mahil, M. Catapano, P. Di Meglio, N. Dand, H. Ahlfors, I. M. Carr, C. H. Smith, R. C. Trembath, M. Peakman, J. Wright, F. D. Ciccarelli, J. N. Barker, F. Capon
Science Translational Medicine, 2017
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A cross-sectional survey of the nature and correlates of sleep disturbance in people with psoriasis
A.L. Henry, S.D. Kyle, A. Chisholm, C.E.M. Griffiths, and C. Bundy
British Journal of Dermatology, 2017      
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The challenges of assessing patients' medication beliefs: a qualitative study
R. J. Thorneloe, C.E.M. Griffiths, D. M. Ashcroft and L. Cordingley
BMC Health Services Research, 2017
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Measurement, Classification and Evaluation of Sleep Disturbance in Psoriasis: A Systematic Review
A.L. Henry, S.D. Kyle, S. Bhandari S, A. Chisholm, C.E.M. Griffiths, and C. Bundy 
PLoS One, 2016
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2011 - 2015

IL36RN mutations define a severe autoinflammatory phenotype of generalized pustular psoriasis.
S. Hussain, D.M. Berki, S.E. Choon, A.D. Burden, M.H. Allen, J.I. Arostegui, A. Chaves, M. Duckworth, A.D. Irvine, M. Mockenhaupt, A. A. Navarini, M.M.B. Seyger, P. Soler-Palacin, C. Prins, L. Valeyrie-Allanore, M. Asuncion Vicente, R.C. Trembath, C.H. Smith, J.N. Barker, F.Capon
Journal of Allergy and Clinical Immunology, 2015
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Activating CARD14 Mutations Are Associated with Generalized Pustular Psoriasis but Rarely Account for Familial Recurrence in Psoriasis Vulgaris
D. M. Berki, L. Liu, S.E. Choon, A. D.Burden, C.E.M. Griffiths, A. A. Navarini, E. S. Tan, A.D. Irvine, A. Ranki, T. Ogo, G. Petrof, S. K. Mahil, M. Duckworth, M. H. Allen, P. Vito, R. C. Trembath, J. McGrath, C. H. Smith, F. Capon, J.N. Barker
Journal of Investigative Dermatology, 2015
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Loss of IL36RN Function Does Not Confer Susceptibility to Psoriasis Vulgaris
D. M. Berki, S.K. Mahil, A. D.Burden, R. C. Trembath, C. H. Smith, F. Capon, J. N. Barker
Journal of Investigative Dermatology, 2014
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Predicting treatment response in psoriasis using serum levels of adalimumab and etanercept: a single-centre, cohort study
S. K. Mahil, Z. Arkir, G. Richards, C. M. Lewis, J. N. Barker, and  C. H. Smith
British Journal of Dermatology, 2013
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Comment on ‘Predicting treatment response in psoriasis using serum levels of adalimumab and etanercept: a single-centre, cohort study’: reply from authors
S. K. Mahil and  C. H. Smith
British Journal of Dermatology, 2013
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Skin treatments for chronic plaque psoriasis
A.R. Mason, J. Mason, M. Cork, G. Dooley, H. Hancock 
Cochrane Database of Systematic Reviews, 2013
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Topical treatments for chronic plaque psoriasis: An abridged Cochrane Systematic Review
A. Mason, J. Mason, M. Cork, H. Hancock, G. Dooley
Journal of the American Academy of Dermatology, 2013 
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Topical treatments for chronic plaque psoriasis of the scalp: a systematic review
A.R. Mason, J. Mason, M. Cork, H. Hancock, G. Dooley
British Journal of Dermatology, 2013
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Predominance of activated, clonally expanded T helper type 17 cells within the CD4+ T cell population in psoriatic lesions.
B. J. Lewis, S. Rajpara, A. M. Haggart, H. M. Wilson, R.N. Barker, and A. D. Ormerod
Clinical Experimental Immunology, 2013
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Adherence to medication in patients with psoriasis: a systemic literature review
R. J. Thorneloe, C. Bundy, C.E.M. Griffiths, D.M. Ashcroft, L. Cordingley
British Journal of Dermatology, 2013
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A pilot randomized controlled trial to examine the feasibility and efficacy of an educational nursing intervention to improve self-management practices in patients with mild-moderate psoriasis.
S. J. Ersser, F. C. Cowdell, P. G. Nicholls, S. M. Latter, and E. Healy
Journal of the European Academy of Dermatology and Venereology, 2011
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Keratinocyte Apoptosis in Epidermal Remodelling and Clearance of Psoriasis Induced by UV Radiation.
S. C. Weatherhead, P.M. Farr, D. Jamieson, J. S. Hallinan, J. J. Lloyd, A. Wipat, N. J. Reynolds
Journal of Investigative Dermatology, 2011
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2006 - 2010

Self-management experiences in adults with mild–moderate psoriasis: an exploratory study and implications for improved support
S. J. Ersser, F. C. Cowdell, S. M. Latter, and E. Healy
British Journal of Dermatology, 2010
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Skin conditions in the UK : a health care needs assessment.
J. Schofield, D. Grindlay and H. Williams
ISBN 13 978 085358 261 8, Centre of Evidence Based Dermatology, 2009
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Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes
M. Quaranta, A. D. Burden, C. E. M. Griffiths, J. Worthington, J. N. Barker, R. C. Trembath and F. Capon
Genes and Immunity, 2009
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Severely Photosensitive Psoriasis: A Phenotypically Defined Patient Subset
K. J. Rutter, R.E.B. Watson, L. F. Cotterell, T. Brenn, C.E.M. Griffiths, L.E. Rhodes
Journal of Investigative Dermatology, 2009
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Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease.
N. Wolf, M. Quaranta, N. J. Prescott, M. Allen, R. Smith, A. D. Burden, J. Worthington, C. E. M. Griffiths, C. G. Mathew, J. N. Barker, F. Capon, R. C. Trembath
Journal of Medical Genetics, 2008
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Identification of ZNF313 / RNF114 as a novel psoriasis susceptibility gene
F. Capon, M. J. Bijlmakers, N. Wolf, M. Quaranta, U. Huffmeier, M. Allen, K. Timms, V. Abkevich, A. Gutin, R. Smith, R. B. Warren, H. S. Young, J. Worthington, A. D. Burden, C. E.M. Griffiths, A. Hayday, F. O. Nestle, A. Reis, J. Lanchbury, J. N. Barker, R. C. Trembath
Human Molecular Genetics, 2008
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G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFκB serine 536 phosphorylation in human keratinocytes
F. G. Goh, C. M. Sloss, M. R. Cunningham, M. Nilsson, L. Cadalbert, R. Plevin
Cellular Signalling, 2008
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Inhibition of calcium-independent phospholipase A impairs agonist-induced calcium entry in keratinocytes.
K. Ross, G. Parker, M. Whitaker, and N. J. Reynolds
British Journal of Dermatology, 2008
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β-Papillomaviruses and psoriasis: an intra-patient comparison of human papillomavirus carriage in skin and hair
J. G. Cronin, D. Mesher, K. Purdie, H. Evans, J. Breuer, C. A. Harwood, J. M. McGregor, and  C. M. Proby
British Journal of Dermatology, 2008
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The Psoriatic Transcriptome Closely Resembles That Induced by Interleukin-1 in Cultured Keratinocytes, Dominance of Innate Immune Responses in Psoriasis
J. B. Mee, C. M. Johnson, N. Morar, F. Burslem, and R. W. Groves
The American Journal of Pathology, 2007
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Increased Blood Levels of IgG Reactive with Secreted Streptococcus pyogenes Proteins in Chronic Plaque Psoriasis
R. G. El-Rachkidy, J. M. Hales, P. P.E. Freestone, H. S. Young, C. E.M. Griffiths, R. D.R. Camp
Journal of Investigative Dermatology, 2007
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2000 - 2005

Vitamin D receptor gene polymorphisms, particularly the novel A-1012G promoter polymorphism, are associated with vitamin D3 responsiveness and non-familial susceptibility in psoriasis
J. A. Halsall, J. E. Osborne, J. H. Pringle, P. E. Hutchinson
Pharmacogenetics and Genomics, 2005
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Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin
E. Campalani, M. H. Allen, D. Fairhurst, H. S. Young, C. O. Mendonca, A. D. Burden, C. E. M. Griffiths, M. A. Crook, J. N. W. N. Barker, and C. H. Smith
British Journal of Dermatology, 2005
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The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial
S.J.R. Allan, G.M. Kavanagh, R.M. Herd, J.A.Savin
British Journal of Dermatology, 2004
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Psychological Distress Impairs Clearance of Psoriasis in Patients Treated With Photochemotherapy
G. Fortune, H. L. Richards, B. Kirby, K. McElhone, T. Markham, S. Rogers, C. J. Main, C. E. M. Griffiths.
Archives of Dermatology, 2003
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Attentional Bias for Psoriasis-Specific and Psychosocial Threat in Patients with Psoriasis
D.G. Fortune, H. L. Richards, A. Corrin, R. J. Taylor, C. E. M. Griffiths, C. J. Main
Journal of Behavioural Medicine, 2003
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Identification of a novel psoriasis susceptibility locus at 1p and evidence of epistasis between PSORS1 and candidate loci
C. D. Veal, R. L. Clough, R. C. Barber, S. Mason, D. Tillman, B. Ferry, A. B. Jones, M. Ameen, N. Balendran, S. H. Powis, A. D. Burden, J. N. W. N. Barker, R. C. Trembath
Journal of Medical Genetics, 2001
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1990s

Psoriatic keratinocytes show reduced IRF-1 and STAT 1-alpha activation in response to gamma-IFN
M. Jackson, S. E. M. Howie, R. Weller, E. Sabin, J. A. A. Hunter, R. C. McKenzie
The FASEB Journal, 1999
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Novel Genetic Association Between the Corneodesmosin (MHC S) Gene and Susceptibility to Psoriasis
R. Tazi Ahnini, N. J. Camp, M. J. Cork, J. B. Mee, S. G. Keohane, G. W. Duff, F. S. di Giovine
Human Molecular Genetics, 1999
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The antiproliferative effect of lectin from the edible mushroom (Agaricus bisporus) on human keratinocytes: preliminary studies on its use in psoriasis
Parslew, Jones, Rhodes and Sharpe
British Journal of Dermatology, 1999
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Characterization of the Major Susceptibility Region for Psoriasis at Chromosome 6p21.3
N. Balendran, R. L. Clough, J. R. Arguello, R. Barber, C. Veal, A. B. Jones, J. L. Rosbotham, A. M. Little, A. Madrigal, J. N.W.N. Barker, S. H. Powis, R. C. Trembath
Journal of Investigative Dermatology, 1999
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Antigen Receptor β Chain Variable Region Usage by CD4+ and CD8+ T Cells in Psoriasis
R. D. R. Camp, M. A. Vekony
Journal of Investigative Dermatology, 1998
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Vitamin D Receptor Polymorphism and Calcipotriol Response in Patients with Psoriasis
J. B. Mee, M. J. Cork
Journal of Investigative Dermatology, 1998
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Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis
R. C. Trembath, R. L. Clough, J. L. Rosbotham, A. B. Jones, R. D. R. Camp, A. Frodsham, J. Browne, R. Barber, J. Terwilliger, G. M. Lathrop and J. N. W. N. Barker
Human Molecular Genetics, 1997
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Postal questionnaire study of disability in the community associated with psoriasis
P. O'Neill and P. Kelly
British Journal of Dermatology, 1996
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Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis
J. M. Carroll, M. R. Romero, F. M.Watt
Cell, 1995
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Up-Regulation of p21WAF1/CIP1 in Psoriasis and After the Application of Irritants and Tape Stripping
E. Healy, N. J. Reynolds, M. D. Smith, D. Harrison, E. Doherty, C. Campbell, J. L. Rees
Journal of Investigative Dermatology, 1995
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Down-regulation of Langerhans cell protein kinase C-β isoenzyme expression in inflammatory and hyperplastic dermatoses
N. J. Reynolds, J. Y. Yi, G. J. Fisher, K. D. Cooper, J. J. Voorhees and C. E. M. Griffiths
British Journal of Dermatology, 1995
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Differential inhibition of cutaneous T-cell-mediated reactions and epidermal cell proliferation by cyclosporin A, FK-506, and rapamycin.
J. I. Duncan
Journal of Investigative Dermatology, 1994
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Blood mononuclear cells from patients with psoriasis exhibit an enhanced adherence to cultured vascular endothelium
F. Leroy, K. A. Brown, M. W. Greaves, A. J. Vora, B. Slavin, M. Robinson, B. A. Ellis, P. M. Dowd, D. C. Dumonde
Journal of Investigative Dermatology, 1991
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1980s

The Effect of Supplementation with Selenium and Vitamin E in Psoriasis
G. M. Fairris, B. Lloyd, L. Hinks, P. J. Perkins and B. E. Clayton
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1989
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An investigation of the ability of antipsoriatic drugs to inhibit calmodulin activity: a possible mode of action of dithranol (anthralin)
W. F. Tucker, S. MacNeil, R. A. Dawson, S. Tomlinson, S. S. Bleehen
Journal of Investigative Dermatology, 1986
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Effect of ischemia and reperfusion of pig skin flaps on epidermal glycogen metabolism
C. S. Harmon, M. R. Masser, P. J. Phizackerley
Journal of Investigative Dermatology, 1986
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A Study of Uniaxial Tension on the Superficial Dermal Microvasculature
R. L. Barnhill, D. L. Bader, T. J. Ryan
Journal of Investigative Dermatology, 1984
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Biochemical Modulation of Angiogenesis in the Chorioallantoic Membrane of the Chick Embryo
R. L. Barnhill, and T. J. Ryan
Journal of Investigative Dermatology, 1983
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The effects of starvation and re-feeding on glycogen metabolism in mouse tail skin.
C. S. Harmon, P. J. Phizackerley 
Biochemical Journal, 1983 
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Thesis Library

The availability of a thesis will depend on whether it has been embargoed, which means that the thesis has been completed but no-one can read it yet. The embargo can last for months or years. This allows the researcher time to publish their work as research papers before the thesis becomes available.

2019

A role for connexin-mediated signalling events in the pathogenesis of psoriasis
Erin O'Shaughnessy, supervised by Dr Patricia Martin, Professor Ann Graham, Dr Sue Lang, Dr Mozheh Zamiri and Dr William Duffy
Glasgow Caledonian University

Characterisation of novel pathogenic pathways for generalised pustular psoriasis
Marika Catapano, supervised by Dr Francesca Capon
King's College London

2018

Psoriasis and sleep deprivation
Alasdair Henry, supervised by Professor Chris Bundy, Dr Simon Kyle and Dr Anna Chisholm
University of Manchester

An investigation into genetic factors which discriminate psoriasis from psoriatic arthritis
Eftychia Bellou, supervised by Professor Richard Warren, Dr John Bowes and Professor Anne Barton
University of Manchester

2017

Oxidised lipids and their role in the immunopathology of psoriasis
Michael Olding, supervised by Dr Tim Millar, Dr Mike Arden-Jones and Professor Eugene Healy
University of Southampton
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The role of exercise on cardiovascular disease risk in psoriasis
Lisa Auker, supervised by Dr Helen Young, Professor Christopher Griffiths and Dr Lis Cordingley
University of Manchester

2016

The Genetic Basis of Pustular Psoriasis and its Overlap with Psoriasis Vulgaris
Dorottya Maria Berki, supervised by Dr Francesca Capon, Professor Richard Trembath and Professor Jonathan Barker
King's College London                                                                       
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2014

Investigating medication adherence in psoriasis: Exploring the role of illness perceptions, medication beliefs, and emotional distress
Rachael Jane Thorneloe, supervised by Dr Lis Cordingley, Professor Darren Ashcroft and Professor Christopher Griffiths
University of Manchester
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2012

A molecular genetic analysis of Crohn's disease susceptibility loci in psoriasis
Maria Quaranta, supervised by Dr Francesca Capon, Professor Richard Trembath and Professor Jonathan Barker
King's College London
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