Systemic Treatments

Systemic medicines affect the entire body (or 'system') rather than just targeting one area, as with topicals (creams and ointments) or UV therapy.

Systemics are able to be prescribed by a Dermatologist for moderate to severe psoriasis which has not successfully responded to topical treatments or UV therapy, or for those who cannot have more cycles of UV therapy. Some systemics can also be used to treat psoriatic arthritis. If the first systemic treatment does not have acceptable results, or if the individual can’t carry on taking it due to side effects or other safety concerns, a second systemic will usually be tried.

The systemics that are most commonly used to treat psoriasis in the UK are Methotrexate, Ciclosporin and Acitretin.

Click on the links below to find out more about the different types of systemic available to treat psoriasis.




Otezla (Apremilast)

Skilarence (Dimethyl Fumarate)

For more information, or for a list of resources used in the production of this information, please contact us.