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29 June 2018

Psoriasis Biologic Draft-Approved for Psoriatic Arthritis

You may have heard about Taltz (also known as ixekizumab), a biologic medication approved last year for the treatment of moderate to severe psoriasis.

The National Institute for Health and Care Excellence has today published its Final Appraisal Determination on the use of Taltz for psoriatic arthritis in England and Wales. Taltz is recommended to treat psoriatic arthritis in the following circumstances:

  • The psoriatic arthritis is ‘active and progressive’ – for example, if you have three or more tender joints, and three or more swollen joints

  • The psoriatic arthritis has not responded well to at least two treatments from the conventional systemic DMARD category

  • The psoriatic arthritis has not responded well, or has stopped responding, to a biologic treatment from the Anti-TNF category

Taltz binds to a cytokine (chemical messenger) called interleukin-17A (IL-17A), which is involved in the body’s inflammatory and immune responses. By binding to IL-17A, Taltz inhibits its action (ie. stops it from working as it usually does). This means Taltz interrupts the inflammatory cycle of psoriasis and psoriatic arthritis, which can lead to the improvement in symptoms for many people who take it.

Like other biologic treatments for psoriasis and psoriatic arthritis, Taltz is taken via injection. It is an immunosuppressive treatment – meaning it reduces the activity of part of the immune system thought to be involved in psoriasis.  You can read more information on the action of Taltz, as well as its dosing regime and possible side effects by downloading our information sheet.

The Psoriasis Association is the UK's leading national charity and membership organisation for people affected by psoriasis – patients, families, carers and health professionals Read More >

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