Research Collaborations

The Psoriasis Association is proud of its commitment to research. In addition to funding our own research, we recognise the importance of working collaboratively with others carrying out research into this complex condition.

Please use the links below to learn more about the various psoriasis research programmes that we are involved with.

Psoriasis Stratification to Optimise Relevant Therapy (PSORT)

Every person with psoriasis is different, and it is well known that what works for one person at any one time wont necessarily work for another. Treating psoriasis is, for most people, a process of trial and error to find the treatment- or combination of treatments- that works for them.

PSORT logoThe PSORT study aims to identify biomarkers found in people's DNA which will help to predict which treatments will not only work best to improve their psoriasis, but also which will work long-term and have the fewest side effects. It has been set up as the result of a £5million funding investment from the Medical Research Council (MRC) and an additional £2million contribution from industry partners. The four-year study will develop a targeted approach to treatment which could soon become reality for people with psoriasis - an approach known as stratified medicine. During the four-year study, the team will collect and evaluate comprehensive information on 7,000 patients including responses (good and bad) to biological therapies.

The research team, known as Psoriasis Stratification to Optimise Relevant Therapy (PSORT) is a unique partnership between five UK universities: Manchester, Kings College London, Newcastle, Queen Mary and Liverpool; 10 pharmaceutical and diagnostics companies; and the Psoriasis Association and NHS partners representing patients.

Click here to visit the PSORT website.

Anakinra for Pustular Psoriasis: Response in a Controlled Trial (APRICOT)

Pustular psoriasis is an uncommon but painful and often debilitating form of psoriasis. We are pleased to be involved with a new clinical trial study specifically for palmo-plantar pustulosis (pustular psoriasis of the palms of the hands and soles of the feet, otherwise known as 'PPP'). 

APRICOT trial logo (website news)Recent research has shown that PPP may be caused by an abnormal pathway in the body's immune system, involving a protein called interleukin-1 (IL-1). The medication being tested - anakinra - specifically blocks this IL-1 pathway, and this clinical trial sets out to test if it therefore improves PPP.

As well as testing anakinra as a potential new treatment for PPP, this trial also hopes to collect information from participants that will help to explain why and how people get PPP. 

APRICOT collaborators, including the Psoriasis Association, are based around the country, have been involved in the project from the beginning, and will also be instrumental in influencing the direction of the trial as part of the trial management group. This clinical trial is lead by Professor Catherine Smith at St John's Institute of Dermatology, and has been funded by the Efficacy and Mechanism Evaluation (EME) Programme, a Medical Research Council and National Institute for Health Research partnership.

The APRICOT study has recently passed its 'half way recruitment target', however 32 new participants are still required to start as soon as possible. APRICOT is currently open at centres in Bradford, Bristol, Cambridge, Cardiff, Derby, Dudley, Dundee, Harlow, Lancaster, Liverpool, London, Newcastle, Norwich, Poole, and Salford. New centres in Chelmsford, Exeter, Fife, Glasgow, Nottingham and Sheffield are also due to open very soon.

For more information on APRICOT, including how to take part in the clinical trial, please visit the website.

  • British Association of Dermatologists Biologic Interventions Register (BADBIR)

Biologic therapies are relatively new treatments for psoriasis. Though fully licensed, there is a need to analyse the long term safety of these treatments as clinical trials are conducted over a fairly short period of time.

BADBIR logoBADBIR is an observational study that will address this question of long-term safety and compare it to the safety of older systemic treatments such as methotrexate. People using biologics or systemic treatments will be invited to join BADBIR by their Dermatologist, if they meet the inclusion criteria.

Upon joining, BADBIR will collect some general information such as demographic, overall health, psoriasis severity and treatments used. They will then confidentially collect updates on treatments, psoriasis severity and any side effects or illnesses until the study ends in 2028. BADBIR will also ask participants to complete a questionnaire about their quality of life during the first three years in the study.

This data will help to build up an overall picture of the long term safety and side effects of biologics. It will also reveal whether biologics are better, worse or the same as older systemic treatments when it comes to long term safety and side effect. This will allow people with psoriasis, and their Dermatologists, to make a more informed decision about their treatments.

For more information, please visit http://www.badbir.org/Participants/

The Psoriasis Association is the UK's leading national charity and membership organisation for people affected by psoriasis – patients, families, carers and health professionals Read More >

Get in touch

The Psoriasis Association Dick Coles House 2 Queensbridge Northampton NN4 7BF

Email: mail@psoriasis-association.org.uk

Tel :
01604 251 620
Fax :
01604 251 621
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